دانشگاه علوم پزشکی ایران
Iran University of Medical Sciences

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افیلیشن های  استاندارد مرکز تحقیقات

مرکز تحقیقات علوم دارویی رازی،
دانشگاه علوم پزشکی ایران، تهران، ایران.


Razi Drug Research Center,
Iran University of Medical Sciences, Tehran, Iran.

دکتر سپیده صفری

 | تاریخ ارسال: ۱۳۹۶/۱۲/۱۳ | 
      نام: سپیده

      نام خانوادگی: صفری

      سمت: هیئت علمی

      رتبه علمی: استادیار

      آخرین مدرک تحصیلی: دکتری

     گرایش: فارماسیوتیکس

     ایمیل: safari.s @iums.ac.ir

     شماره تماس: 86703145

 

RESEARCH INTERESTS
  1. Gene delivery
  2. Preformulation studies
  3. Drug delivery systems
 
UNIVERSITY EDUCATION 2005 Pharm. D. (Doctor of Pharmacy) Tehran University of Medical Sciences, Tehran, Iran Thesis: Invitro-Invivo (pharmacokinetic and pharmacodynamic parameters) Modeling of gliclazide. 2012 Ph.D. (Pharmaceutics) Tehran University of Medical Sciences, Tehran, Iran Thesis: Evaluation and preparation of chitosan based injectable implant for intratumoral gene delivery. 2013 Postdoctoral Department of Biomedical Engineering, University of Florida, USA Research Title: Preparation and characterization of Chitosan/magnetic nanoparticles for gene delivery.
RESEARCH PAPERS
  1. S. Safari, F.A. Dorkoosh, M. Soleimani, M.H. Zarrintan, H. Akbari, B. Larijani, M. Rafiee Tehrani, N-Diethylmethyl chitosan for gene delivery to pancreatic cancer cells and the relation between charge ratio and biologic properties of polyplexes via interpolations polynomial. International Journal of Pharmaceutics, 420 (2011) 350– 357.
  1. S. Safari, M.H. Zarrintan, M. Soleimani, F. A. Dorkoosh, H. Akbari, B. Larijani, M. Rafiee Tehrani, Evaluation and optimization of chitosan derivatives-based gene delivery system via kidney epithelial cells. Advanced Pharmaceutical Bulletin, 2012, 2(1), 7-16.
  1. S. Safari, F.A. Dorkoosh, M. Soleimani, M.H. Zarrintan, H. Akbari, B. Larijani, M. Rafiee Tehrani, Evaluating gene delivery using N- triethyl chitosan nanoparticles to AsPC-1 cells and predicting the relation between transfection, cytotoxicity and charge ratio of polyplexes via mathematical models.  Drug delivery letters, 2013,3,2-11
  2. S. Safari, H. Akbari , M. Soleimani, M. H. Zarrintan, F.A. Dorkoosh , B. Larijani, M.A. Oghabian, M. Rafiee Tehrani, Chitosan-based intratumoral injectable nanoparticles for gene delivery to pancreatic cancer cells. IJPSR, 2013; Vol. 4(10): 3850-3856.
  1. Morteza Rafiee Tehrani, Sepideh Safari, Soona Jafari, Mohsen Amini, Mohammad Hossein Ghahremani, Naser Ostad .Gene Delivery Using N-Diethylmethyl Chitosan to Hela Cell Line. Control. Rel. J., 2012, 1:34-38
  1. Negar Ghalandarlaki, Noorahmad Latifi, Mehdi Mirzaei, Mohammad T. Joghatei , Sepideh Safari , Khadijeh Ashtari and Bita MehraviIn Vitro evaluation of Gd3+- anionic linear glubolar dendrimer -Monoclonal Antibody:     Potential Magnetic Resonance Imaging Contrast Agents for prostate cancer cell imaging.   Current Molecular Imaging, 2015, 4, 35-42.
  1. Bita Mehravi, Ali Mohammad Alizadeh, Saeed Khodayari, Hamid Khodayari, Khadijeh Ashtari, Mojdeh Mohseni, Neda Iranpour Anaraki, Elham Afjeh Dana, Sepideh Safari, Massoud Amanlou. Acute Toxicity Evaluation of Glycosylated Gd3+-Based Silica Nanoprobe. Molecular Imaging and Biology, 2016.
  1. Neda Iranpour Anaraki, Mojdeh Mohseni, Khadijeh Ashrari, Mehdi Mirzaei, Sepideh Safari, Elham Mohammadi, Salar Hooshyar, Roya Ilka, Marzieh Abnoos, Sima Shojaei, Nayereh Niazi, Bita Mehravi*. Folic acid decorated mesoporous silica nanospheres loaded with Gadolinium for Breast Cancer cell imaging. Submitted
  1. The effect of chronic administration of nandrolone decanoate along with severe endurance exercise on some parameters of adipo-cardiovascular axis. Manijeh Motevalian1, Siyavash Joukar*2, 3, 4, Saeed Esmaeeli Mahani5, Abdollah Karimi3, Yaser Masoumi-Ardakani3, Sepideh Safari1 .Submitted
 
 
ABSTRACTS
  1. N, N-Diethyl N-Methyl and N-Triethyl chitosan as nanocarrier for gene delivery to pancreatic cancer cells (ICNN 2010)
  2. Pancreatic Cancer Cells Gene Delivery Using Chitosan Derivative and the Relation between Charge Ratio and Biologic Properties of Polyplexes via Polynomial Interpolations (ICNFA 2011)
  3. Intratumoral Injection of Chitosan-based Gene Delivery Vector to Pancreatic Cancer Cells (CRS 2011)
  4. Gene Delivery to Pancreatic Cancer Cells via Intratumoral Injection of Chitosan-based Vector (MECRC & ICRC 2014): accepted for oral presentation
 
TALKS
  1. Targeted therapy in cancer. Tehran university of medical sciences (2007)
  2. Passive tumour targeting of polymer-coated adenovirus for cancer gene therapy. Tehran university of medical sciences (2007)
  3. Biodegradable polycation and plasmid DNA multilayer film for prolonged gene delivery to mouse osteoblasts. Tehran university of medical sciences (2008)
  4.  Nanoparticles as potential oral delivery systems of proteins. Tehran university of medical sciences ( 2009)
  5. Evaluating a Chitosan Derivative for Gene Delivery to Pancreatic Cancer Cells via Invitro Studies and Interpolations Polynomial Method.  (ICRC 2011)
  6. Mesenchymal stem cells engineered for cancer therapy. Tehran university of medical sciences (2012)
  7.  Preparation of chitosan based injectable implant for intratumoral gene delivery. Stem cell technology institute (2012)
  8. Preparation and characterization of Chitosan/magnetic nanoparticles for gene delivery. University of Florida, Department of biomedical engineering (2013)
  9. Impact of preformulation on drug development. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran (2017)
 
RESEARCH PROJECTS
  1. Executer, (Tehran University of Medical Sciences) (2009-2012). Evaluation and preparation of chitosan based injectable implant for intratumoral gene delivery.
  2. Executer, (Iran University of Medical Sciences, Razi Drug Research Center). Proposal No: 30270,  (2017). Preformulation studies of bioactive compound from Gum Ammoniacum: Extraction, evaluation of analgesic/anti-inflammatory acticity and structre determination.
  3. Executer, (Iran University of Medical Sciences, Razi Drug Research Center). Proposal No: 29959,  (2017). Extraction and evaluation of antiepileptic activity of compounds from Gum Ammoniacum.
  4. Executer, (Iran University of Medical Sciences, Razi Drug Research Center). Proposal No: 31423, (2017). Preparation and evaluation of chitosan-fatty acid nanoparticles for gene delivery to mucosal cells
  5. Supervisor, (Tehran University of Medical Sciences) (2017). Gene delivery to the mucosal cells using novel chitosan derivative nanoparticles
  6. Colleague, (Iran University of Medical Sciences, Razi Drug Research Center) (2017). Pharmacophore Modeling and Virtual Screening (CFTCR) Models Using Computational Methods: Docking and Simulation of Molecular Dynamics
  7. Colleague, (Iran University of Medical Sciences, Razi Drug Research Center) (2017). Comparison of the effect of intra-nasal and oral administration of Sunitib drug in rats in the glioblastoma cellular disease model of the C9-induced cell line
 
TEACHING EXPERIENCES
  1. Physical Pharmacy, International Campus Pharmacy, Iran University of Medical Sciences
  2. Novel Drug Delivery, Faculty of Advanced Medical Technology, Iran University of Medical Sciences
 
POSITIONS HELD AND PROFESSIONAL ACTIVITES
  1. Biological drugs expert at Food and Drug Organization (FDO),  2012
  2. Section editor in Iranian journal of pharmacology and therapeutics (IJPR) at Razi Drug Research Center, Iran University of Medical Sciences (2016-present)

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